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The ongoing research in the laboratory is predicated upon two main concepts. Firstly, rhythmic limb movements are controlled in part by collections of neurons found in the spinal cord. These collectives are together termed “central pattern generators” or CPGs. Secondly, the regulation of smooth rhythmic movement involves reciprocal interactions between the supraspinal structures in the brain, the spinal cord CPGs, and feedback due to movement of the arms and legs. These are conceptually illustrated in the diagram. In our experiments we ask subjects to perform rhythmic movements of the arms or legs such as during walking or arm cycling. We then probe the neural control mechanisms by electrically stimulating nerves in the arms and legs. Reflexes are evoked by this stimulation and we use the reflexes to inform us about the neural control of the movements.
Projects currently underway in the laboratory include those aimed at better understanding the linkages between all three parts shown on the diagram. There are specific projects focussed on improving our understanding of these linkages in participants without neurological injury and those who have suffered neurotrauma (stroke or spinal cord injury). We are currently investigating these relationships during walking and arm cycling in both neurologically intact and neurotrauma participants in an effort to develop new rehabilitative interventions for motor recovery.
Dr. E Paul Zehr	[About the lab] [People] [Facilities] [Media Coverage] [Funding] [Seminars] [Experiments Scheduled]