Publications

pzehr@uvic.ca

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Highlighted Publications

 

E. P. Zehr and A. Kido, “Reflexes in a forearm flexor muscle by stimulation of different cutaneous nerves during rhythmic arm movement” in: Neural control of rhythmic, cyclical human arm movement: task dependency, nerve specificity, and phase modulation of cutaneous reflexes, this issue pp. 1033-1045.

Rhythmic arm movement suppresses reflex amplitudes in the leg. Subjects performed rhythmic arm cycling and H-reflexes were evoked in the ankle extensor muscles. The mannequin is shown performing arm cycling, and the EMG traces show the inhibition of reflex amplitude (yellow line) from control (red line). Shown in the watermark are the suggested mechanisms regulating the pattern of reflex modulation, including supraspinal inputs and spinal central pattern generators (CPGs) active during movement. From: Frigon A, Collins DF, and Zehr EP. Effect of rhythmic arm movement on reflexes in the legs: modulation of soleus H-reflexes and somatosensory conditioning. J Neurophysiol. December 3, 2003; 10.1152/jn.00695.2003.

Moving from the cat to man. Movement of the limbs during human locomotion is mediated in large part by spinal mechanisms. These mechanisms (shown as spinal cord sections on the human skeleton) play a similar coordinative role as those in the cat. Traces of reflex and locomotor EMG are shown disappearing into the distance under the seated cat while the human walks away to the right. See article by E. Paul Zehr and Jacques Duysens beginning on page 347 in this issue.

Click on any of the images above to see inside journal! (pdf format)

Please find below some selections from my publications organized under 3 of the main themes of my research program.

NEURAL CONTROL OF RHYTHMIC MOVEMENT

Zehr, E.P., J.E. Balter, D.P. Ferris , S.R. Hundza, P. Loadman, and R. Stoloff (2007). Neural regulation of rhythmic arm and leg movement is conserved across human locomotor tasks. J Physiol (Lond) 582:209-227

Stoloff, R., Zehr, E.P., and Ferris, D.P. (2007) Recumbent stepping has similar but simpler neural control compared to walking. Exp Brain Res 178:427-438

Carroll, T.J., Baldwin, E.R.L.,Collins, D.F., and Zehr, E.P. (2006) Corticospinal excitability is lower during rhythmic arm movement than during tonic contraction. J. Neurophysiol. 95:914-21

Zehr, E.P. (2005) Neural control of rhythmic human movement: the common core hypothesis. Exercise and Sport Sciences Reviews 33:54-60

Zehr, E.P., and Hundza, S.R. (2005) Forward and backward arm cycling are regulated by equivalent neural mechanisms. J Neurophysiol 93:633-640.

Zehr, E.P., Carroll, T.J., Chua, R., Collins, D.F., Frigon, A., Haridas, C., Hundza, S.R., and Kido, A. (2004). Possible contributions of spinal CPG activity to rhythmic human arm movement. Can J Physiol. Pharm. 82(8/9):566-568.

Zehr, E.P., Haridas, C. (2003) Modulation of cutaneous reflexes in arm muscles during walking: further evidence for similar control mechanisms for rhythmic human arm and leg movements Exp Brain Res. 149:260-266.

Zehr, E.P., Collins, D.F., Frigon, A., Hoogenboom, N. (2003) Neural control of cyclical human arm movement: phase-dependence and task modulation Hoffmann reflexes J. Neurophysiol. 89:12-21.

Zehr, E.P., Kido, A. (2001) Neural control of rhythmic, cyclical human arm movement: task-dependency, nerve-specificity, and phase-modulation of cutaneous reflexes. J. Physiol. 537:1033-1045.

Zehr, E.P., Fujita, K., and Stein, R.B. (1998). Reflexes from the superficial peroneal nerve during walking in stroke subjects. J. Neurophysiol. 79(2):848-858.

NEURAL COUPLING BETWEEN THE ARMS AND LEGS DURING LOCOMOTION

Barzi, Y., and Zehr E.P. (2008) Rhythmic arm cycling suppresses hyperactive Soleus H-reflex amplitude after stroke. Clin Neurophysiol 119:1443-1452

Balter, J.E., and Zehr, E.P. (2007) Neural coupling between the arms and legs during rhythmic locomotor-like cycling movement. J Neurophysiol 97:1809-1818

Zehr, E.P., M. Klimstra, K. Dragert, Y. Barzi, M.G. Bowden, B. Javan, and C. Phadke (2007). Enhancement of arm and leg locomotor coupling with augmented cutaneous feedback from the hand. J Neurophysiol 98:1810-1814

Lamont, E.V., and Zehr, E.P. (2007). Earth-referenced hand rail contact facilitates interlimb cutaneous reflexes during locomotion. J Neurophysiol 98: 433-442.

Zehr, E.P., M. Klimstra, E.A. Johnson, and T.J. Carroll. (2007) Rhythmic leg cycling modulates forearm muscle H-reflex amplitude and corticospinal tract excitability. Neurosci Lett 419:10-14.

Loadman, P., and Zehr,E.P. (2007) Rhythmic arm cycling produces a non-specific signal of generalized activity that suppresses Soleus H-reflex amplitude in stationary legs. Exp Brain Res. 179:199-208. Balter, J.E., and Zehr, E.P. (2007) Neural coupling between the arms and legs during rhythmic locomotor-like cycling movement. J Neurophysiol 97:1809-1818.

Haridas, C., Zehr, E.P., and Misiaszek, J.E. (2006) Context-Dependent Modulation of Interlimb Cutaneous Reflexes in Arm Muscles as a Function of Stability Threat During Walking. J Neurophysiol 96:3096-3103.

Zehr, E.P., Hoogenboom, N., Frigon, A.F., and Collins, D.F. (2004). Facilitation of soleus H-reflex amplitude evoked by cutaneous nerve stimulation at the wrist is not suppressed by rhythmic arm movement.  Exp Brain Res.159: 382-388.

Zehr, E.P., Duysens, J. (2004) Regulation of arm and leg movement during human locomotion. The Neuroscientist 10(4): 347-361

Frigon, A.F., Collins, D.F., and Zehr, E.P. (2004) Effect of arm movement on reflexes in the legs: modulation of soleus H-reflexes and somatosensory conditioning. J Neurophysiol. 91:1516-1523.

Haridas, C., and Zehr, E.P. (2003) Coordinated interlimb compensatory responses to electrical stimulation of cutaneous nerves in the hand and foot during walking. J Neurophysiol 90:2850-2861.

Zehr, E.P., Collins, D.F., and Chua, R. (2001). Human interlimb reflexes evoked by electrical stimulation of cutaneous nerves innervating the hand and foot. Exp. Brain Res. 140:495-504.


NEUROMUSCULAR PLASTICITY

Javan, B., and Zehr, E.P. (2008) Short-term plasticity of spinal reflex excitability induced by rhythmic arm movement. J Neurophysiol 99:2000-2005.

Zehr, E.P. (2006) Training-induced adaptive plasticity in human somatosensory reflex pathways. J Appl Physiol 101:1783-1794.

Lagerquist, O., Zehr, E.P., and Docherty, D. (2006) Increased Spinal Reflex Excitability is Not Responsible For Neural Plasticity Underlying the Cross Education Effect. J Appl Physiol. 100:83-90

Lagerquist, O., Zehr, E.P., Collins, D.F., Baldwin, R.L., and Klacowicz, P.M. (2006) Diurnal changes in the amplitude of the Hoffmann reflex in human soleus but not flexor carpi radialis muscle. Exp Brain Res. 170:1-6.

Zehr, E.P. (2002) Considerations for use of the Hoffmann reflex in exercise studies. Eur. J. Appl. Physiol. 86:455-468.

Zehr, E.P., Sale , D.G. and Dowling, J.J. (1997). Ballistic movement in karate athletes. Med. Sci. Sports Exerc. 29:1366-1373.

Zehr, E.P. and Sale , D.G. (1994). Ballistic movement: muscle activation and neuromuscular adaptation. Can.J. Appl. Physiol. 19(4):363-378.

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